Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical | Zendy

Aaron M. Fleming | Zendy; Cynthia J. Burrows | Zendy

Open Access

Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical

Author(s) -

Aaron M. Fleming,

Cynthia J. Burrows

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc04138f

Subject(s) - chemistry , deoxyguanosine , bicarbonate , oxidizing agent , hydroxyl radical , carbonate , yield (engineering) , radical , photochemistry , inorganic chemistry , oxygen , radical ion , reactive oxygen species , ion , nuclear chemistry , organic chemistry , adduct , biochemistry , materials science , metallurgy

Product analysis from the iron Fenton oxidation of 2'-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2'-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙-. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.

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