Open AccessQuantifying the effects of quadrupolar sinksvia15N relaxation dynamics in metronidazoles hyperpolarizedviaSABRE-SHEATH
Author(s) -
Jonathan R Birchall,
Mohammad Shah Hafez Kabir,
Oleg G. Salnikov,
Н. В. Чуканов,
Alexandra Svyatova,
Kirill V. Kovtunov,
Igor V. Koptyug,
Juri G. Gelovani,
Boyd M. Goodson,
Wellington Pham,
Eduard Y. Chekmenev
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc03994b
Subject(s) - relaxation (psychology) , dynamics (music) , chemistry , nuclear magnetic resonance , physics , materials science , psychology , social psychology , acoustics
15 N spin-lattice relaxation dynamics in metronidazole- 15 N 3 and metronidazole- 15 N 2 isotopologues are studied for rational design of 15 N-enriched biomolecules for signal amplification by reversible exchange in microtesla fields. 15 N relaxation dynamics mapping reveals the deleterious effects of interactions with the polarization transfer catalyst and a quadrupolar 14 N nucleus within the spin-relayed 15 N- 15 N network.