Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles | Zendy

Jun Zhao | Zendy; Graham C. R. EllisDavies | Zendy

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Intracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles

Author(s) -

Jun Zhao,

Graham C. R. EllisDavies

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc03956j

Subject(s) - neuropharmacology , nanoparticle , azobenzene , nanotechnology , luminescence , isomerization , chemistry , biophysics , materials science , neuroscience , optoelectronics , biology , biochemistry , molecule , organic chemistry , catalysis

Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for "remote control" of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.

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