Open AccessIntracellular photoswitchable neuropharmacology driven by luminescence from upconverting nanoparticles
Author(s) -
Jun Zhao,
Graham C. R. EllisDavies
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc03956j
Subject(s) - neuropharmacology , nanoparticle , azobenzene , nanotechnology , luminescence , isomerization , chemistry , biophysics , materials science , neuroscience , optoelectronics , biology , biochemistry , molecule , organic chemistry , catalysis
Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb nanoparticles can be used for "remote control" of an azobenzene-based photochromic ion channel blocker of neurons in living brain slices.