The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer | Zendy

Thomas Scattolin | Zendy; Enrica Bortolamiol | Zendy; Stefano Palazzolo | Zendy; Isabella Caligiuri | Zendy; Tiziana Perin | Zendy; Vincenzo Canzonieri | Zendy; Nicola Demitri | Zendy; Flavio Rizzolio | Zendy; Luigi Cavallo | Zendy; Büşra Dereli | Zendy; Manoj V. Mane | Zendy; Steven P. Nolan | Zendy; Fabiano Visentin | Zendy

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The anticancer activity of an air-stable Pd(i)-NHC (NHC = N-heterocyclic carbene) dimer

Author(s) -

Thomas Scattolin,

Enrica Bortolamiol,

Stefano Palazzolo,

Isabella Caligiuri,

Tiziana Perin,

Vincenzo Canzonieri,

Nicola Demitri,

Flavio Rizzolio,

Luigi Cavallo,

Büşra Dereli,

Manoj V. Mane,

Steven P. Nolan,

Fabiano Visentin

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc03883k

Subject(s) - carbene , dimer , chemistry , cancer cell lines , stereochemistry , medicinal chemistry , combinatorial chemistry , cancer cell , cancer , organic chemistry , catalysis , biology , genetics

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

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