Open AccessA fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1–3Gal epitope
Author(s) -
Jiaxing Wang,
Beverly A. Ellis,
Bin Zhou,
Lisa M. Eubanks,
Steven Blake,
Kim D. Janda
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc02107e
Subject(s) - epitope , antibody , chemistry , virology , microbiology and biotechnology , medicine , immunology , biology
A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.