Open AccessSelf-assembly of chimeric peptides toward molecularly defined hexamers with controlled multivalent ligand presentation
Author(s) -
Xiushuang Yuan,
Linhai Jiang,
Weike Chen,
Bo Song,
Wei Chen,
Xiaobing Zuo,
Xiankai Sun,
Xiaopeng Li,
Kent Kirshenbaum,
Shizhong Luo,
He Dong
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc02066d
Subject(s) - random hexamer , ligand (biochemistry) , chemistry , peptide , biophysics , combinatorial chemistry , crystallography , receptor , biochemistry , biology
This work demonstrates a self-assembling peptide strategy to form finite, molecularly defined trigonal bipyramidal-like hexamers which offer control over multivalent ligand display for enhanced tumor targeting.
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