Open AccessSolid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy
Author(s) -
Nicholas G. Paciaroni,
John M. Ndungu,
Thomas Kodadek
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc01474e
Subject(s) - aldehyde , dna , combinatorial chemistry , chemistry , dna synthesis , solid phase synthesis , computer science , organic chemistry , biochemistry , catalysis , peptide
We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.