Sequence-directed dynamic covalent assembly of base-4-encoded oligomers | Zendy

Samuel C. Leguizamon | Zendy; Megan F. Dunn | Zendy; Timothy F. Scott | Zendy

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Sequence-directed dynamic covalent assembly of base-4-encoded oligomers

Author(s) -

Samuel C. Leguizamon,

Megan F. Dunn,

Timothy F. Scott

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/d0cc01083a

Subject(s) - peptoid , covalent bond , nucleobase , dna , base pair , sequence (biology) , chemistry , residue (chemistry) , base sequence , stereochemistry , nanotechnology , combinatorial chemistry , biochemistry , materials science , peptide , organic chemistry

As an information-bearing biomacromolecule, DNA is encoded in base-4, where each residue site can be occupied by any one of four nucleobases. Mimicking the information dense, sequence-selective hybridization of DNA, we demonstrate two orthogonal dynamic covalent interactions to effect the selective assembly of molecular ladders and grids from base-4-encoded oligo(peptoid)s.

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