Open AccessTemplate-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry
Author(s) -
Aline Umuhire Juru,
Zhipeng Cai,
Adina Jan,
Amanda E. Hargrove
Publication year - 2020
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/d0cc00266f
Subject(s) - imine , chemistry , combinatorial chemistry , selection (genetic algorithm) , computational biology , computer science , biochemistry , biology , catalysis , machine learning
This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.