Open AccessTargeted nanoscale therapeutics for myocardial infarction
Author(s) -
Holly L. Sullivan,
Nathan C. Gianneschi,
Karen L. Christman
Publication year - 2021
Publication title -
biomaterials science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.422
H-Index - 64
eISSN - 2047-4849
pISSN - 2047-4830
DOI - 10.1039/d0bm01677b
Subject(s) - myocardial infarction , medicine , nanoscopic scale , cardiology , pharmacology , nanotechnology , materials science
Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.