Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation | Zendy

Benjamin M. Richardson | Zendy; Cierra J. Walker | Zendy; Laura J. Macdougall | Zendy; Jack W. Hoye | Zendy; Mark A. Randolph | Zendy; Stephanie J. Bryant | Zendy; Kristi S. Anseth | Zendy

Open Access

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

Author(s) -

Benjamin M. Richardson,

Cierra J. Walker,

Laura J. Macdougall,

Jack W. Hoye,

Mark A. Randolph,

Stephanie J. Bryant,

Kristi S. Anseth

Publication year - 2020

Publication title -

biomaterials science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.422

H-Index - 64

eISSN - 2047-4849

pISSN - 2047-4830

DOI - 10.1039/d0bm00860e

Subject(s) - self healing hydrogels , viscoelasticity , ethylene glycol , morphology (biology) , hydrazone , chondrocyte , polymer chemistry , chemistry , chemical engineering , biophysics , polymer science , materials science , composite material , organic chemistry , biochemistry , biology , in vitro , genetics , engineering

Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).

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