Open AccessCoherent anti-Stokes Raman scattering imaging of microcalcifications associated with breast cancer
Author(s) -
Georgi I. Petrov,
Rajan Arora,
Vladislav V. Yakovlev
Publication year - 2021
Publication title -
analyst (london. 1877. online)/analyst
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 153
eISSN - 1364-5528
pISSN - 0003-2654
DOI - 10.1039/d0an01962c
Subject(s) - raman scattering , breast cancer , raman spectroscopy , scattering , medicine , materials science , optics , radiology , nuclear magnetic resonance , nuclear medicine , pathology , physics , cancer
Chemical imaging of calcifications was demonstrated in the depth of a tissue. Using long wavelength excitation, broadband coherent anti-Stokes Raman scattering and hierarchical cluster analysis, imaging and chemical analysis were performed 2 mm below the skin level in a model system. Applications to breast cancer diagnostics and imaging are discussed together with the methods to further extend the depth and improve the spatial resolution of chemical imaging.