Open AccessConvection-driven microfabricated hydrogels for rapid biosensing
Author(s) -
Cheng Cheng,
Mark H. Harpster,
John Oakey
Publication year - 2020
Publication title -
analyst (london. 1877. online)/analyst
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 153
eISSN - 1364-5528
pISSN - 0003-2654
DOI - 10.1039/d0an01069c
Subject(s) - microscale chemistry , biosensor , analyte , self healing hydrogels , nanotechnology , materials science , chemistry , chromatography , polymer chemistry , mathematics education , mathematics
A microscale biosensing platform using rehydration-mediated swelling of bio-functionalized hydrogel structures and rapid target analyte capture is described. Induced convective flow mitigates diffusion limited incubation times, enabling model assays to be completed in under three minutes. Assay design parameters have been evaluated, revealing fabrication criteria required to tune detection sensitivity.