Open AccessDifferent solid forms for optimizing route of administration of the herpes drug Pritelivir
Author(s) -
Helga RuebsamenSchaeff,
Helmut Buschmann
Publication year - 2019
Publication title -
medchemcomm
Language(s) - English
Resource type - Journals
eISSN - 2040-2511
pISSN - 2040-2503
DOI - 10.1039/c9md00233b
Subject(s) - drug , administration (probate law) , pharmacology , drug administration , business , computer science , medicine , political science , law
Pritelivir (AIC316, BAY 57-1293) was discovered as a highly potent drug against herpes simplex viruses with a novel mode of action, i.e. inhibition of the viral helicase-primase. A side by side comparison of the oral form against Valtrex™ in patients with genital herpes, showed superiority in phase II testing for Pritelivir. A number of different solid forms have been generated for additional, e.g. systemic, or topical applications.
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