A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging | Zendy

Hong Liang | Zendy; Qunjie Bi | Zendy; Ao Hu | Zendy; Xiaobing Chen | Zendy; Rongrong Jin | Zendy; Xu Song | Zendy; Bowen Ke | Zendy; Matthias Barz | Zendy; Yu Nie | Zendy

Open Access

A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging

Author(s) -

Hong Liang,

Qunjie Bi,

Ao Hu,

Xiaobing Chen,

Rongrong Jin,

Xu Song,

Bowen Ke,

Matthias Barz,

Yu Nie

Publication year - 2020

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc10071g

Subject(s) - nitroreductase , glutathione , indocyanine green , chemistry , fluorescence , biophysics , biochemistry , combinatorial chemistry , gene , enzyme , biology , medicine , optics , physics , surgery

A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.

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