Open AccessSimple and robust polymer-based sensor for rapid cancer detection using serum
Author(s) -
Ngoc D. B. Le,
Arvind K. Singla,
Yingying Geng,
Jinsong Han,
Kai Seehafer,
G. C. Prakash,
Daniel F. Moyano,
Charlene M. Downey,
Michael J. Monument,
Doha Itani,
Uwe H. F. Bunz,
Frank R. Jirik,
Vincent M. Rotello
Publication year - 2019
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc04854e
Subject(s) - simple (philosophy) , polymer , cancer detection , cancer , materials science , chemistry , nanotechnology , computer science , combinatorial chemistry , medicine , organic chemistry , philosophy , epistemology
We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.