Open AccessA biomimetic cerium-based biosensor for the direct visual detection of phosphate under physiological conditions
Author(s) -
Thibaud Rossel,
Marc Creus
Publication year - 2019
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc04840e
Subject(s) - naked eye , phosphate , chemistry , cerium , aqueous solution , aqueous medium , biosensor , ion , homoleptic , inorganic chemistry , combinatorial chemistry , nuclear chemistry , chromatography , detection limit , biochemistry , organic chemistry , metal
An indicator displacement assay (IDA) was used to probe phosphate ions in an aqueous medium at neutral pH using a dinuclear cerium based complex [Ce2(HXTA)]3+. The homoleptic complex can be used to detect phosphate ions with nanomolar affinity either spectrophotometrically or with the naked-eye. To our knowledge, this is the first dinuclear cerium biomimetic IDA detection system with the highest affinity known to date for selective, naked-eye based phosphate recognition under physiological conditions (pH = 5-7) and even in pure water and complex samples such as sea water.
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