Open AccessSingle photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes
Author(s) -
Kanchan Basnet,
Tayebeh Fatemipouya,
Anna St Lorenz,
Mindy Nguyen,
Oleh Taratula,
Maged Henary,
Kathryn B. Grant
Publication year - 2019
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/c9cc04751d
Subject(s) - quinoline , chromophore , photochemistry , chemistry , radical , dna , two photon excitation microscopy , excitation , irradiation , wavelength , excitation wavelength , optoelectronics , materials science , organic chemistry , nuclear physics , electrical engineering , engineering , biochemistry , physics
We have synthesized symmetrical carbocyanine dyes in which two 4-quinolinium rings are joined by a pentamethine bridge that is meso-substituted with H or Cl. Irradiation of the halogenated dye at 830 nm produces hydroxyl radicals that generate DNA direct strand breaks. This represents the first reported example of DNA photocleavage upon single photon excitation of a chromophore at wavelengths above 800 nm.