Probing membrane enhanced protein–protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase | Zendy

Mukesh Mahajan | Zendy; Thirupathi Ravula | Zendy; Elke Prade | Zendy; G.M. Anantharamaiah | Zendy; Ayyalusamy Ramamoorthy | Zendy

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Probing membrane enhanced protein–protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase

Author(s) -

Mukesh Mahajan,

Thirupathi Ravula,

Elke Prade,

G.M. Anantharamaiah,

Ayyalusamy Ramamoorthy

Publication year - 2019

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c9cc01630a

Subject(s) - redox , cytochrome p450 , chemistry , cytochrome p450 reductase , reductase , enzyme , biochemistry , cytochrome c , cytochrome , coenzyme q – cytochrome c reductase , mitochondrion , organic chemistry

Investigating the interplay in a minimal redox complex of cytochrome-P450 and its reductase is crucial for understanding cytochrome-P450's enzymatic activity. Probing the hotspots of dynamic structural interactions using NMR revealed the engagement of loop residues from P450-reductase to be responsible for the enhanced affinity of CYP450 towards its obligate redox partner.

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