Open AccessSynthesis of six-membered spirooxindolesviaa chiral Brønsted acid-catalyzed asymmetric intramolecular Friedel–Crafts reaction
Author(s) -
Hui-Xuan Chen,
Yaqi Zhang,
Yuyang Zhang,
Xuefeng He,
Zhenwei Zhang,
Hao Liu,
Wenhuan He,
Xiaoding Jiang,
Xiangmeng Chen,
Liqin Qiu
Publication year - 2018
Publication title -
rsc advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.746
H-Index - 148
ISSN - 2046-2069
DOI - 10.1039/c8ra06710d
Subject(s) - stereocenter , intramolecular force , phosphoric acid , indoline , brønsted–lowry acid–base theory , catalysis , chemistry , friedel–crafts reaction , medicinal chemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis
A chiral phosphoric acid-catalyzed asymmetric intramolecular Friedel–Crafts reaction for the synthesis of 3′,4′-dihydro-2′ H -spiro[indoline-3,1′-pyrrolo[1,2- a ]pyrazin]-2-ones.