Peroxidase mimicking DNAzymes degrade graphene oxide | Zendy

Rajendra Kurapati | Zendy; Alberto Bianco | Zendy

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Peroxidase mimicking DNAzymes degrade graphene oxide

Author(s) -

Rajendra Kurapati,

Alberto Bianco

Publication year - 2018

Publication title -

nanoscale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.038

H-Index - 224

eISSN - 2040-3372

pISSN - 2040-3364

DOI - 10.1039/c8nr06535g

Subject(s) - graphene , deoxyribozyme , horseradish peroxidase , hemin , peroxidase , hydrogen peroxide , oxide , guanine , dna , chemistry , materials science , photochemistry , nanotechnology , biochemistry , enzyme , heme , organic chemistry , nucleotide , gene

DNAzymes made of supramolecular guanine-rich G-quadruplexes and hemin are attracting a lot of interest due to their peroxidase activity mimicking the natural enzyme horseradish peroxidase (HRP). Herein, we demonstrate that DNAzyme consisting of a PS2.M-hemin complex can be an alternative to natural HRP for the oxidation and degradation of graphene oxide (GO). The degradation of GO sheets was carried out by incubating the PS2.M-hemin complex in the presence of hydrogen peroxide for 30 days. The degradation of GO has been confirmed using transmission electron microscopy and 2d Raman mapping. The current study suggests that the peroxidase activity of DNAzymes is similar to HRP and DNAzymes are able to degrade carbon-based nanomaterials.

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