Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs | Zendy

M. ter Meer | Zendy; Ross Dillion | Zendy; Signe Maria Nielsen | Zendy; Raoul Walther | Zendy; Rikke Louise Meyer | Zendy; Willeke F. Daamen | Zendy; Lambertus P. van den Heuvel | Zendy; J. Adam van der Vliet | Zendy; Roger M. L. M. Lomme | Zendy; Yvonne L. Hoogeveen | Zendy; Leo J. Schultze Kool | Zendy; Jeremy E. Schaffer | Zendy; Alexander N. Zelikin | Zendy

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Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

Author(s) -

M. ter Meer,

Ross Dillion,

Signe Maria Nielsen,

Raoul Walther,

Rikke Louise Meyer,

Willeke F. Daamen,

Lambertus P. van den Heuvel,

J. Adam van der Vliet,

Roger M. L. M. Lomme,

Yvonne L. Hoogeveen,

Leo J. Schultze Kool,

Jeremy E. Schaffer,

Alexander N. Zelikin

Publication year - 2018

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c8cc08737g

Subject(s) - glycosidic bond , prodrug , antibacterial activity , combinatorial chemistry , metal , chemistry , nanotechnology , materials science , bacteria , organic chemistry , biochemistry , biology , genetics , enzyme

Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.

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