Open AccessA simple and facile NMR method for the determination of hydrogen bonding by amide N–H protons in protein models and other compounds
Author(s) -
Michael H. Abraham,
Raymond J. Abraham
Publication year - 2017
Publication title -
new journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.693
H-Index - 122
eISSN - 1369-9261
pISSN - 1144-0546
DOI - 10.1039/c7nj01044c
Subject(s) - chemistry , amide , chloroform , hydrogen bond , proton nmr , chemical shift , hydrogen , stereochemistry , organic chemistry , molecule
It is shown that measurements of the 1 H chemical shifts of amide N–H protons in chloroform and in DMSO solvents are sufficient to determine the extent of hydrogen bonding of the N–H protons in a variety of compounds containing the amide group.