Cysteine and glutathione trigger the Cu–Zn swap between Cu(ii)-amyloid-β4-16peptide and Zn7-metallothionein-3 | Zendy

Alice Santoro | Zendy; Nina E. Wezynfeld | Zendy; Milan Vašák | Zendy; Wojciech Bal | Zendy; Peter Faller | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cysteine and glutathione trigger the Cu–Zn swap between Cu(ii)-amyloid-β_4-16peptide and Zn₇-metallothionein-3

Author(s) -

Alice Santoro,

Nina E. Wezynfeld,

Milan Vašák,

Wojciech Bal,

Peter Faller

Publication year - 2017

Publication title -

chemical communications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.837

H-Index - 333

eISSN - 1364-548X

pISSN - 1359-7345

DOI - 10.1039/c7cc06802f

Subject(s) - metallothionein , cysteine , glutathione , peptide , chemistry , swap (finance) , zinc , biochemistry , enzyme , organic chemistry , finance , economics

Cysteine and glutathione are able to reduce Cu(ii) coordinated to the peptide amyloidβ4-16, and shuttle the resulting Cu(i) to partially replace Zn(ii) in the protein Zn7-metallothionein-3. The released Zn(ii) in turn binds to amyloid-β4-16. Thus cysteine and glutathione are modulators of Cu/Zn-distribution between metallothionein-3 and amyloid-β4-16

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research