Open AccessCatalytic cyclization and competitive deactivation with Ru(PR2NR′2) complexes
Author(s) -
James M. Stubbs,
J.-P. J. Bow,
Richard J. Hazlehurst,
Johanna M. Blacquiere
Publication year - 2016
Publication title -
dalton transactions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 184
eISSN - 1477-9234
pISSN - 1477-9226
DOI - 10.1039/c6dt03694e
Subject(s) - catalysis , chemistry , medicinal chemistry , stereochemistry , organic chemistry
The first successful use of the P R 2 N R' 2 (1,5-R'-3,7-R-1,5-diaza-3,7-diphosphacyclooctane) ligand family toward an organic synthesis is described. The precatalysts [Ru(Cp)(P R 2 N Bn 2 )(MeCN)]PF 6 are active toward cyclization of 2-ethynylbenzyl alcohol at low catalyst loading and mild temperatures. Catalyst performance however is limited by both low conscription and by competitive deactivation.
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