NMR study on the interaction of the conserved CREX ‘stem–loop’ in the Hepatitis E virus genome with a naphthyridine-based ligand | Zendy

Natalia Dyubankova | Zendy; Matheus Froeyen | Zendy; Mikhail Abramov | Zendy; HenriPhilippe Mattelaer | Zendy; Piet Herdewijn | Zendy; Eveline Lescrinier | Zendy

Open Access

NMR study on the interaction of the conserved CREX ‘stem–loop’ in the Hepatitis E virus genome with a naphthyridine-based ligand

Author(s) -

Natalia Dyubankova,

Matheus Froeyen,

Mikhail Abramov,

HenriPhilippe Mattelaer,

Piet Herdewijn,

Eveline Lescrinier

Publication year - 2015

Publication title -

organic and biomolecular chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.923

H-Index - 146

eISSN - 1477-0539

pISSN - 1477-0520

DOI - 10.1039/c5ob01381j

Subject(s) - chemistry , rna , guanine , genome , dna , loop (graph theory) , hepatitis c virus , ligand (biochemistry) , nucleic acid , virology , virus , crystallography , biochemistry , gene , nucleotide , biology , combinatorics , receptor , mathematics

A 2-amino-1,8-naphthyridine derivative that is described to bind single guanine bulges in RNA-DNA and RNA-RNA duplexes was synthesized and its interaction with the single G bulge in the conserved CREX of the Hepatitis E Virus (HEV) genome was explored by NMR and molecular modeling. Results indicate that the ligand intercalates in the internal loop, though none of the expected hydrogen bonds with the single G in the bulge could be demonstrated.

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