Transition metal-catalyzed redox isomerization of codeine and morphine in water | Zendy

Antonio Bermejo Gómez | Zendy; Pär Holmberg | Zendy; JanE. Bäckvall | Zendy; Belén MartínMatute | Zendy

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Transition metal-catalyzed redox isomerization of codeine and morphine in water

Author(s) -

Antonio Bermejo Gómez,

Pär Holmberg,

JanE. Bäckvall,

Belén MartínMatute

Publication year - 2014

Publication title -

rsc advances

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.746

H-Index - 148

ISSN - 2046-2069

DOI - 10.1039/c4ra07735k

Subject(s) - hydrocodone , isomerization , hydromorphone , chemistry , codeine , catalysis , transition metal , rhodium , redox , morphine , metal , precious metal , inorganic chemistry , opioid , organic chemistry , oxycodone , medicine , biochemistry , receptor , pharmacology

A water-soluble rhodium complex formed from commercially available [Rh(COD)(CH3CN)(2)]BF4 and 1,3,5-triaza-7-phosphaadamantane (PTA) catalyzes the isomerization of both codeine and morphine into hydrocodone and hydromorphone with very high efficiency. The reaction is performed in water, allowing isolation of the final products by simple filtration, which results in very high isolated yields. The reactions can be easily scaled up to 100 g.

AuthorCount:4;

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