Open AccessNovel type of metallation reaction: cyclometallation of heterocyclic amines by dicyclopentadienylmethyltitanium
Author(s) -
Bert Klei,
Jan H. Teuben
Publication year - 1978
Publication title -
journal of the chemical society chemical communications
Language(s) - English
Resource type - Journals
eISSN - 2050-5639
pISSN - 0022-4936
DOI - 10.1039/c39780000659
Subject(s) - chemistry , medicinal chemistry , stereochemistry , combinatorial chemistry
In a new type of metallation reaction 2-substituted pyridines and quinolines are metallated at the 6- and 2-position, respectively by dicyclopentadienylmethyltitanium prepared in situ
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