Correlative light-ion microscopy for biological applications | Zendy

Sérgio Bertazzo | Zendy; Thomas von Erlach | Zendy; Silvia Goldoni | Zendy; Pelin L. Candarlioglu | Zendy; Molly M. Stevens | Zendy

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Correlative light-ion microscopy for biological applications

Author(s) -

Sérgio Bertazzo,

Thomas von Erlach,

Silvia Goldoni,

Pelin L. Candarlioglu,

Molly M. Stevens

Publication year - 2012

Publication title -

nanoscale

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.038

H-Index - 224

eISSN - 2040-3372

pISSN - 2040-3364

DOI - 10.1039/c2nr30431g

Subject(s) - correlative , microscopy , fluorescence , fluorescence microscope , nanoscopic scale , nanotechnology , substrate (aquarium) , materials science , resolution (logic) , in situ , biological system , computer science , biophysics , chemistry , optics , biology , artificial intelligence , physics , ecology , philosophy , linguistics , organic chemistry

Here we report a new technique, Correlative Light-Ion Microscopy (CLIM), to correlate SEM-like micrographs with fluorescence images. This technique presents significant advantages over conventional methods in enabling topographical and biochemical information to be correlated with nanoscale resolution without destroying the fluorescence signal. We demonstrate the utility of CLIM for a variety of investigations of cell substrate interactions validating its potential to become a routine procedure in biomedical research.

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