The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity | Zendy

Ewa Kurowska | Zendy; Joanna Sasin-Kurowska | Zendy; Arkadiusz Bonna | Zendy; Marcin Grynberg | Zendy; Jarosław Poznański | Zendy; Łukasz Kniżewski | Zendy; Krzysztof Ginalski | Zendy; Wojciech Bal | Zendy

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The C2H2 zinc finger transcription factors are likely targets for Ni(ii) toxicity

Author(s) -

Ewa Kurowska,

Joanna Sasin-Kurowska,

Arkadiusz Bonna,

Marcin Grynberg,

Jarosław Poznański,

Łukasz Kniżewski,

Krzysztof Ginalski,

Wojciech Bal

Publication year - 2011

Publication title -

metallomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 75

eISSN - 1756-591X

pISSN - 1756-5901

DOI - 10.1039/c1mt00081k

Subject(s) - zinc finger , zinc , hydrolysis , transcription factor , chemistry , peptide , transcription (linguistics) , sp1 transcription factor , nickel , intracellular , zinc finger transcription factor , toxicity , biochemistry , promoter , gene , gene expression , organic chemistry , linguistics , philosophy

Ni(II) ions are able to hydrolyze Naa-(Ser/Thr) peptide bonds in Naa-(Ser/Thr)-Xaa-His-Zaa sequences. We found that various human transcription factors contain such nickel hydrolytic patterns within C2H2 zinc finger (ZF) domains. We demonstrated the hydrolysis on two peptide models, the 3rd ZF of the Sp1 transcription factor and the 1st ZF of the ZNF302 transcription factor. The experimentally studied reaction rates indicate that the hydrolysis reaction is likely to be an element of intracellular nickel toxicity.

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