Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite | Zendy

Estefanı́a Delgado-Pinar | Zendy; M. Teresa Albelda | Zendy; Juan C. Frías | Zendy; Olga Barreiro | Zendy; Emilio Tejera | Zendy; Vojtěch Kubíček | Zendy; Luis Jesús JiménezBorreguero | Zendy; Francisco SánchezMadrid | Zendy; Éva Tóth | Zendy; Javier Alarcón | Zendy; Enrique GarcíaEspaña | Zendy

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Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite

Author(s) -

Estefanı́a Delgado-Pinar,

M. Teresa Albelda,

Juan C. Frías,

Olga Barreiro,

Emilio Tejera,

Vojtěch Kubíček,

Luis Jesús JiménezBorreguero,

Francisco SánchezMadrid,

Éva Tóth,

Javier Alarcón,

Enrique GarcíaEspaña

Publication year - 2011

Publication title -

dalton transactions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 184

eISSN - 1477-9234

pISSN - 1477-9226

DOI - 10.1039/c1dt10389j

Subject(s) - boehmite , lanthanide , fluorescence , nanoparticle , hela , confocal , materials science , characterization (materials science) , microscopy , chelation , dispersion (optics) , confocal microscopy , chemistry , nanotechnology , in vitro , organic chemistry , optics , ion , aluminium , biochemistry , physics

The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.

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