The frequently overlooked importance of solvent in free radical syntheses | Zendy

Grzegorz Litwinienko | Zendy; A. L. J. BECKWITH | Zendy; K. U. Ingold | Zendy

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The frequently overlooked importance of solvent in free radical syntheses

Author(s) -

Grzegorz Litwinienko,

A. L. J. BECKWITH,

K. U. Ingold

Publication year - 2011

Publication title -

chemical society reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.598

H-Index - 513

eISSN - 1460-4744

pISSN - 0306-0012

DOI - 10.1039/c1cs15007c

Subject(s) - chemistry , solvent , organic chemistry , biochemical engineering , combinatorial chemistry , computational chemistry , engineering

This tutorial review is designed to dispel the myth, still believed by many synthetic organic chemists, that radical-based syntheses are free from significant solvent effects. However, many synthetically valuable radical reactions do exhibit large kinetic solvent effects. It is therefore important to select the solvent for any proposed radical synthesis with considerable care if good product yields are to be achieved.

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