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Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling
Author(s) -
Stefano Moro,
Francesca Deflorian,
Giampiero Spalluto,
Giorgia Pastorin,
Barbara Cacciari,
SooKyung Kim,
Kenneth A. Jacobson
Publication year - 2003
Publication title -
chemical communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.837
H-Index - 333
eISSN - 1364-548X
pISSN - 1359-7345
DOI - 10.1039/b303439a
Subject(s) - g protein coupled receptor , receptor , adenosine receptor , computational biology , reciprocal , adenosine , chemistry , neuroscience , computer science , biology , biochemistry , philosophy , linguistics , agonist
We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.

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