Open AccessA new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells
Author(s) -
Dongpeng Li,
Zhaoyang Wang,
Jie Cui,
Xin Wang,
Miao Jiang,
BaoXiang Zhao
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep45294
Subject(s) - förster resonance energy transfer , fluorescence , sulfur dioxide , chemistry , endogeny , selectivity , liver cancer , sulfur , cancer cell , energy transfer , detection limit , biophysics , cancer , biochemistry , biology , chromatography , inorganic chemistry , optics , organic chemistry , physics , genetics , catalysis , molecular physics
A new ratiometric fluorescent probe was constructed with hemicyanine and 7-nitrobenzofurazan for detection of sulfur dioxide derivatives (HSO 3 − /SO 3 2− ). The ratiometric response mode could be attributed to the efficient FRET (Förster resonance energy transfer) platform. The probe exbihited some desirable properties including fast response (within 2 minutes), good selectivity and high sensitivity. Moreover, the probe could detect endogenous HSO 3 − in liver cancer cells rather than normal liver cells, implying the diagnosal potential of the probe.