Open AccessGenomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease
Author(s) -
Dan Yin,
Duraid Hamied Naji,
Yunlong Xia,
Sisi Li,
Ying Bai,
Guiqing Jiang,
Yuanyuan Zhao,
Xiaojing Wang,
Yufeng Huang,
Shanshan Chen,
Jingjing Fa,
Chibing Tan,
Ming Zhou,
Yingchao Zhou,
Long Wang,
Feifei Chen,
Ying Liu,
Qiuyun Chen,
Xin Tu,
Chengqi Xu,
Qing Kenneth Wang
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep42175
Subject(s) - coronary artery disease , single nucleotide polymorphism , allele , medicine , case control study , genetics , population , genetic association , biology , cad , polymorphism (computer science) , gene , bioinformatics , immunology , oncology , genotype , biochemistry , environmental health
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37 , the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association analysis between rs3811047 and CAD in two independent populations with 2,501 patients and 3,116 controls from China. Quantitative RT-PCR analysis has been performed to determine if the IL-37 expression level is influenced by rs3811047. We show that the minor allele A of rs3811047 is significantly associated with CAD in two independent populations under a recessive model ( P adj = 5.51 × 10 −3 /OR = 1.56 in the GeneID Northernern population and P adj = 1.23 × 10 −3 /OR = 1.45 in the GeneID Central population). The association became more significant in the combined population ( P adj = 9.70 × 10 −6 /OR = 1.47). Moreover, the association remains significant in a CAD case control population matched for age and sex. Allele A of rs3811047 shows significant association with a decreased mRNA expression level of IL-37 (n = 168, P = 3.78 × 10 −4 ). These data suggest that IL37 is a new susceptibility gene for CAD, which provides a potential target for the prevention and treatment of CAD.