Aptamer-PEG-modified Fe3O4@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells | Zendy

Haitao Zhu | Zendy; Lirong Zhang | Zendy; Yanfang Liu | Zendy; Yuepeng Zhou | Zendy; Kang Wang | Zendy; Xiaodong Xie | Zendy; Song Lian | Zendy; Dongqing Wang | Zendy; Chunlei Han | Zendy; QiuYun Chen | Zendy

Open Access

Aptamer-PEG-modified Fe3O4@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells

Author(s) -

Haitao Zhu,

Lirong Zhang,

Yanfang Liu,

Yuepeng Zhou,

Kang Wang,

Xiaodong Xie,

Song Lian,

Dongqing Wang,

Chunlei Han,

QiuYun Chen

Publication year - 2016

Publication title -

scientific reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.24

H-Index - 213

ISSN - 2045-2322

DOI - 10.1038/srep39245

Subject(s) - aptamer , magnetic resonance imaging , cancer research , in vivo , cancer cell , in vitro , hypoxia (environmental) , stem cell , dual mode , cancer stem cell , metastasis , tumor hypoxia , chemistry , cancer , medicine , microbiology and biotechnology , biology , biochemistry , radiation therapy , organic chemistry , aerospace engineering , oxygen , engineering , radiology

Hypoxia-induced cancer stem cells have been known to be involved in tumour metastasis, resistance to chemo/radio therapy and tumour recurrence. Magnetic Resonance Imaging is a widely used imaging tool for cancers in clinics and research. To develop T1-positive and T2-negative dual mode MRI agents for more comprehensive and accurate diagnostic information under hypoxic conditions, a hypoxia-inducible factor-1α based aptamer and Mn(II)-modified nanoparticles D-Fe 3 O 4 @PMn were synthesized and characterized. In vitro and in vivo studies show that D-Fe 3 O 4 @PMn NPs are biocompatible and less cytotoxic and can produce significant contrast enhancement in T1- and T2-weighted MR imaging. Furthermore, the D-Fe 3 O 4 @PMn NPs enable targeted dual-contrast T1- and T2-weighted MR imaging of cancer cells expressing high levels of HIF-1α and cancer stem cell-related proteins under hypoxic condition. In conclusion, NPs with HIF-1α and Mn(II) are promising diagnostic agents for dual-mode T1 and T2 imaging by targeting cancer stem cells as they are non-toxic and biocompatible.

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