Open AccessThumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters
Author(s) -
Srestha Basu,
Amaresh Kumar Sahoo,
Anumita Paul,
Arun Chattopadhyay
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep39005
Subject(s) - nanoclusters , luminescence , bilirubin , materials science , linear range , fabrication , chitosan , nanotechnology , detection limit , optoelectronics , chemistry , chromatography , medicine , gastroenterology , biochemistry , pathology , alternative medicine
Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu 2+ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu 2+ added, thereby facilitating the detection of the desired concentration range of bilirubin.