Open AccessA nationwide cross-sectional survey on prevalence, management and pharmacoepidemiology patterns on hypertension in Chinese patients with chronic kidney disease
Author(s) -
Wen Zhang,
Wei Shi,
Zhangsuo Liu,
Yong Gu,
Qinkai Chen,
Yuan Wang,
Yanlin Zhang,
Lirong Gong,
Rong Zhou,
Mingxu Li,
Hong Cheng,
Jian Liu,
Jun Cen,
Chaoxing Huang,
Ye-Ping Ren,
Peiju Mao,
Changying Xing,
Fu-Yuan Hong,
Dongsheng Jiang,
Li Wang,
Gang Xu,
Jianshe Liu,
Nan Chen
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep38768
Subject(s) - pharmacoepidemiology , cross sectional study , medicine , kidney disease , disease management , disease , medline , family medicine , chronic disease , pathology , pharmacology , biology , medical prescription , biochemistry , parkinson's disease
Limited data are available on epidemiology and drug use in Chinese hypertensive patients with chronic kidney disease (CKD). We determined the prevalence; awareness, treatment, and control rates of hypertension; anti-hypertensive use, expenditure pattern; and factors associated with hypertension prevalence and control in Chinese patients with CKD. This was one of the largest cross-sectional surveys that enrolled 6079 CKD participants (mean age, 51.0 ± 16.37 years) with or without hypertension from 22 centres across China. The prevalence, awareness, and treatment rates were 71.2%, 95.4%, and 93.7%, respectively. Control rates 1 and 2 (Blood pressure, BP <140/90 and <130/80 mmHg) were 41.1% and 15.0%, respectively. Patients were treated mostly with monotherapy (37.7%) or 2-drug anti-hypertensive combination (38.7%). Factors associated with prevalence of hypertension included age; smoking; body mass index; physical exercise; family history of hypertension; hyperuricaemia; and CKD. Control rate was associated with CKD stage, BP monitoring at home, and use of drug combinations. Despite high rates of awareness and treatment, the control rates are low. CKD stages 4 and 5 adversely affect the control rate. The results suggest the immediate need of comprehensive controlling measures to improve the control of hypertension in Chinese patients with CKD.