Open AccessHelicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease
Author(s) -
Tae Jun Kim,
Hyuk Lee,
Mira Kang,
Jee Eun Kim,
Yoon–Ho Choi,
Min Ye,
Jun Haeng Lee,
Hee Jung Son,
PoongLyul Rhee,
SunYoung Baek,
Soo Hyun Ahn,
Jae J. Kim
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep38015
Subject(s) - medicine , dyslipidemia , body mass index , helicobacter pylori , waist , blood pressure , confounding , gastroenterology , confidence interval , glycated hemoglobin , diabetes mellitus , risk factor , relative risk , obesity , endocrinology , type 2 diabetes
Epidemiologic and clinical data suggest that Helicobacter pylori infection is a contributing factor in the progression of atherosclerosis. However, the specific cardiovascular disease risk factors associated with H. pylori remain unclear. We performed a cross-sectional study of 37,263 consecutive healthy subjects who underwent a routine health check-up. In multivariable log Poisson regression models adjusted for potential confounders, the associations of H. pylori seropositivity with higher LDL-C (relative risk [RR], 1.21; 95% confidence interval [CI], 1.12–1.30) and lower HDL-C level (RR, 1.10; 95% CI, 1.01–1.18) were significant and independent. In multiple linear regression analyses, H. pylori infection was significantly associated with higher total cholesterol level (coefficient = 2.114, P < 0.001), higher LDL-C level (coefficient = 3.339, P < 0.001), lower HDL-C level (coefficient = −1.237, P < 0.001), and higher diastolic blood pressure (coefficient = 0.539, P = 0.001). In contrast, H. pylori infection was not associated with obesity-related parameters (body mass index, waist circumference), glucose tolerance (fasting glucose, glycated hemoglobin), and systolic blood pressure. We found that H. pylori infection was significantly and independently associated with dyslipidemia, but not with other cardiometabolic risk factors, after adjusting for potential risk factors of atherosclerosis.