Open AccessCompound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia
Author(s) -
Jiahua Guo,
Yonghong Yong,
Jiye Aa,
Bei Cao,
Runbin Sun,
Xiaoyi Yu,
Jingqiu Huang,
Na Yang,
Lulu Yan,
Xinxin Li,
Jing Cao,
Nan Aa,
Zhijian Yang,
Xiangqing Kong,
Liansheng Wang,
Xue-Ming Zhu,
Xiaojing Ma,
ZhiXin Guo,
Shuiping Zhou,
He Sun,
Guangji Wang
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep37919
Subject(s) - ischemia , metabolomics , glycolysis , myocardial ischemia , pharmacology , medicine , energy metabolism , metabolism , chemistry , chromatography
The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue. CDDP pretreatment increased energy production, ameliorated biochemical indices, modulated the changes and metabolomic pattern induced by ISO, especially in heart tissue. For the first time, we found that ISO induced myocardial ischemia was accomplished with a reduced fatty acids metabolism and an elevated glycolysis for energy supply upon the ischemic stress; while CDDP pretreatment prevented the tendency induced by ISO and enhanced a metabolic shift towards fatty acids metabolism that conventionally dominates energy supply to cardiac muscle cells. These data suggested that the underlying mechanism of CDDP involved regulating the dominant energy production mode and enhancing a metabolic shift toward fatty acids metabolism in ischemic heart. It was further indicated that CDDP had the potential to prevent myocardial ischemia in clinic.