Open AccessLeft Atrial trajectory impairment in Hypertrophic Cardiomyopathy disclosed by Geometric Morphometrics and Parallel Transport
Author(s) -
Paolo Piras,
Concetta Torromeo,
Federica Re,
A. Evangelista,
Stefano Gabriele,
Giuseppe Esposito,
Paola Nardinocchi,
Luciano Teresi,
Andrea Madeo,
Claudia Chialastri,
Michele Schiariti,
Valerio Varano,
Massimo Uguccioni,
Paolo Puddu
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep34906
Subject(s) - hypertrophic cardiomyopathy , morphometrics , cardiology , trajectory , medicine , speckle tracking echocardiography , left atrium , atrial fibrillation , heart failure , physics , biology , ejection fraction , astronomy , fishery
The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three–dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy. The two trajectories were much different at the transition between LA conduit and booster pump functions. Full shape and deformation analyses with trajectory analysis enabled a straightforward perception of pathophysiological consequences of HCM condition on LA functioning. It might be worthwhile to apply these techniques to look for novel pathophysiological approaches that may better define atrio–ventricular interaction.