Open AccessUnique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis
Author(s) -
Wenjun Liu,
Jiachao Zhang,
Chunyan Wu,
Shunfeng Cai,
Weiqiang Huang,
Jing Chen,
Xiaoxia Xi,
Zebin Liang,
Qiangchuan Hou,
Bing Zhou,
Nan Qin,
Heping Zhang
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep34826
Subject(s) - metagenomics , faecalibacterium prausnitzii , biology , microbiome , gut flora , phylum , gut microbiome , bifidobacterium , shotgun sequencing , zoology , genetics , dna sequencing , immunology , gene , bacteria , lactobacillus
The human gut microbiota varies considerably among world populations due to a variety of factors including genetic background, diet, cultural habits and socioeconomic status. Here we characterized 110 healthy Mongolian adults gut microbiota by shotgun metagenomic sequencing and compared the intestinal microbiome among Mongolians, the Hans and European cohorts. The results showed that the taxonomic profile of intestinal microbiome among cohorts revealed the Actinobaceria and Bifidobacterium were the key microbes contributing to the differences among Mongolians, the Hans and Europeans at the phylum level and genus level, respectively. Metagenomic species analysis indicated that Faecalibacterium prausnitzii and Coprococcus comes were enrich in Mongolian people which might contribute to gut health through anti-inflammatory properties and butyrate production, respectively. On the other hand, the enriched genus Collinsella , biomarker in symptomatic atherosclerosis patients, might be associated with the high morbidity of cardiovascular and cerebrovascular diseases in Mongolian adults. At the functional level, a unique microbial metabolic pathway profile was present in Mongolian’s gut which mainly distributed in amino acid metabolism, carbohydrate metabolism, energy metabolism, lipid metabolism, glycan biosynthesis and metabolism. We can attribute the specific signatures of Mongolian gut microbiome to their unique genotype, dietary habits and living environment.