Open AccessImplementation of Arithmetic and Nonarithmetic Functions on a Label-free and DNA-based Platform
Author(s) -
Kun Wang,
Mengqi He,
Jin Wang,
Ronghuan He,
Jianhua Wang
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep34810
Subject(s) - subtractor , computer science , adder , multiplexer , logic gate , arithmetic , multiplexing , parallel computing , computer architecture , algorithm , mathematics , telecommunications , latency (audio)
A series of complex logic gates were constructed based on graphene oxide and DNA-templated silver nanoclusters to perform both arithmetic and nonarithmetic functions. For the purpose of satisfying the requirements of progressive computational complexity and cost-effectiveness, a label-free and universal platform was developed by integration of various functions, including half adder, half subtractor, multiplexer and demultiplexer. The label-free system avoided laborious modification of biomolecules. The designed DNA-based logic gates can be implemented with readout of near-infrared fluorescence, and exhibit great potential applications in the field of bioimaging as well as disease diagnosis.