Open AccessCharacterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks
Author(s) -
Miaomiao Zhang,
Xingxing Zhang,
K. Xu,
Quincy Teng,
Qinfang Liu,
Xuesong Li,
Jianmei Yang,
Jianqing Xu,
Hongjun Chen,
Xiaoyan Zhang,
Zejun Li
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep34489
Subject(s) - virology , pathogenesis , influenza a virus subtype h5n1 , transmission and infection of h5n1 , biology , h5n1 genetic structure , virus , medicine , immunology , avian influenza virus , covid-19 , pathology , disease , infectious disease (medical specialty)
Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.