Open AccessGlucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding
Author(s) -
Shigetomo Suyama,
Fumihiko Maekawa,
Yuko Maejima,
Naoto Kubota,
Takashi Kadowaki,
Toshihiko Yada
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep30796
Subject(s) - adiponectin , proopiomelanocortin , arcuate nucleus , endocrinology , medicine , arc (geometry) , inhibitory postsynaptic potential , excitatory postsynaptic potential , hypothalamus , chemistry , carbohydrate metabolism , neuron , leptin , biology , diabetes mellitus , insulin resistance , obesity , neuroscience , geometry , mathematics
Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including hypothalamic arcuate nucleus (ARC), where proopiomelanocortin (POMC) neurons play key roles in feeding regulation. Several studies have examined intracerebroventricular (ICV) injection of adiponectin and reported opposite effects, increase or decrease of food intake. These reports used different nutritional states. The present study aimed to clarify whether adiponectin exerts distinct effects on food intake and ARC POMC neurons depending on the glucose concentration. Adiponectin was ICV injected with or without glucose for feeding experiments and administered to ARC slices with high or low glucose for patch clamp experiments. We found that adiponectin at high glucose inhibited POMC neurons and increased food intake while at low glucose it exerted opposite effects. The results demonstrate that glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding.