Open AccessAssociation between Testicular Cancer and Epididymoorchitis: A Population-Based Case-Control Study
Author(s) -
Li Ting Kao,
Herng Ching Lin,
ShiuDong Chung,
Chao-Yuan Huang
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep23079
Subject(s) - confounding , medicine , odds ratio , logistic regression , case control study , conditional logistic regression , cancer , odds , population , environmental health
Even though epididymoorchitis and testicular cancer (TC) may have similar pathophysiological pathways, no prior study has attempted to determine the association between these two diseases. This case-control study investigated the relationship between TC and prior epididymoorchitis by using a large population-based database. We used the Taiwan Longitudinal Health Insurance Database 2005 to select 372 patients who had received a diagnosis of TC and 3,720 age-matched controls without TC. We found that of the total sample of 4,092 patients, 53 (1.3%) had received a diagnosis of epididymoorchitis prior to the index date. Patients with TC had a higher prevalence of prior epididymoorchitis than that of patients without TC (11.0% vs. 0.3%, p < 0.001). Conditional logistic regression showed that prior epididymoorchitis was significantly associated with TC (crude OR = 38.24, 95% CI = 19.91–73.46). The association remained statistically significant even after adjustment for the other variables (OR = 47.17, 95% CI = 23.83–93.40). This study showed that patients with TC have higher odds of prior epididymoorchitis than do those without TC even after adjustment for potential confounders.