Open AccessCC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10
Author(s) -
Florian Hessner,
C. P. Dlugos,
Tarek Chehab,
Christiane Schaefer,
Bernhard Homey,
Volker Gerke,
Thomas Weide,
Hermann Pavenstädt,
Ursula Rescher
Publication year - 2016
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/srep22649
Subject(s) - ccr10 , g protein coupled receptor , chemokine receptor , microbiology and biotechnology , c c chemokine receptor type 6 , biology , receptor , chemokine , signal transduction , biochemistry
The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca 2+ binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.