Innate pathogen recognition in the kidney: Toll-like receptors, NOD-like receptors, and RIG-like helicases | Zendy

HansJoachim Anders | Zendy

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Innate pathogen recognition in the kidney: Toll-like receptors, NOD-like receptors, and RIG-like helicases

Author(s) -

HansJoachim Anders

Publication year - 2007

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/sj.ki.5002436

Subject(s) - receptor , toll , nod , rig i , innate immune system , pattern recognition receptor , biology , pathogen , helicase , pathogen associated molecular pattern , microbiology and biotechnology , toll like receptor , immunology , virology , medicine , genetics , gene , rna

How do infections trigger or aggravate renal pathology? The discovery of the toll-like receptors, and more recently, the retinoic-acid-inducible protein-like helicases and the nucleotide-binding oligomerization domain-like receptors may offer new concepts to answer this question. Common pathogen-associated molecules are recognized by these receptors in several cellular compartments of immune cells and non-immune cells inside the kidney. This article summarizes ligand-receptor interactions and their known or potential significance in kidney diseases.

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