Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats | Zendy

S. Tanda | Zendy; Yasukiyo Mori | Zendy; Taikou Kimura | Zendy; Kazuhiro Sonomura | Zendy; Tetsuro Kusaba | Zendy; N Kishimoto | Zendy; H. Kameyama | Zendy; Keiichi Tamagaki | Zendy; Mitsuhiko Okigaki | Zendy; Tsuguru Hatta | Zendy; Susumu Sasaki | Zendy; K. Takeda | Zendy; Yoshikazu Sado | Zendy; Naoto Adachi | Zendy; Hiroki Matsubara | Zendy

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Histamine ameliorates anti-glomerular basement membrane antibody-induced glomerulonephritis in rats

Author(s) -

S. Tanda,

Yasukiyo Mori,

Taikou Kimura,

Kazuhiro Sonomura,

Tetsuro Kusaba,

N Kishimoto,

H. Kameyama,

Keiichi Tamagaki,

Mitsuhiko Okigaki,

Tsuguru Hatta,

Susumu Sasaki,

K. Takeda,

Yoshikazu Sado,

Naoto Adachi,

Hiroki Matsubara

Publication year - 2007

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/sj.ki.5002370

Subject(s) - glomerular basement membrane , glomerulonephritis , histamine , basement membrane , antibody , kidney glomerulus , medicine , rapidly progressive glomerulonephritis , glomerulus , immunology , endocrinology , chemistry , kidney , pathology

Anti-glomerular basement membrane (anti-GBM)-induced glomerulonephritis involves T-helper type 1 (Th1) responses leading to rapid crescent formation. As many inflammatory and immune responses in general are affected by histamine, we examined the effects of histaminergic ligands on immune renal injury in the rat. Female Wistar-Kyoto rats were injected intraperitoneally with an antibody against the GBMs. Histaminergic ligands were then injected twice daily for 5 days after which renal function was assessed by proteinuria. Treatment with histamine led to significant dose-dependent reductions in proteinuria compared to the control antibody-injected group and markedly decreased the number of crescentic glomeruli and macrophage infiltration of the glomeruli. Furthermore, histamine significantly decreased the plasma concentration of interleukin-12, a Th1-type cytokine compared to the antibody-injected control animals. Dimaprit, an H(2)/H(4) agonist, mimicked the effects of histamine on proteinuria and crescent formation. Clozapine, an H(4) agonist, tended to mimic the effects of histamine, whereas an H(1), mepyramine, or an H(2) antagonist, ranitidine, did not reverse the protective effect of histamine. We suggest that histamine may alleviate renal injury in anti-GBM glomerulonephritis by suppressing the immune response.

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