Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity | Zendy

Susan P. Bagby | Zendy

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Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity

Author(s) -

Susan P. Bagby

Publication year - 2007

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/sj.ki.5002286

Subject(s) - diabetic nephropathy , nephropathy , glomerulosclerosis , diabetes mellitus , medicine , kidney disease , endocrinology , proximal tubule , kidney , pathology , proteinuria

Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.

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